منابع مشابه
Exocytotic Fusion Mode Influence of Synaptic Vesicle Position on Release
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متن کاملRoles of SNARE Proteins in Synaptic Vesicle Fusion
Neurotransmitters are stored in small membrane-bound vesicles at synapses. Neurotransmitter release is initiated by depolarization of the neuron, which in turn activates voltage-gated calcium channels. Calcium influx then triggers the fusion of the synaptic vesicles with the plasma membrane. Fusion of the vesicular and plasma membranes is mediated by SNARE (soluble N-ethylmaleimide– sensitive f...
متن کاملMembrane Curvature in Synaptic Vesicle Fusion and Beyond
Recent evidence suggests that the Ca(2+)-sensors synaptotagmin-1 and Doc2b deform synaptic membranes during synaptic vesicle exocytosis. We discuss how local curvature generated by these and other proteins may stimulate membrane fusion and discuss the potential implications of these findings for other cellular fusion events.
متن کاملSNARE-complex disassembly by NSF follows synaptic-vesicle fusion.
Soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE)-mediated fusion of synaptic vesicles with the presynaptic-plasma membrane is essential for communication between neurons. Disassembly of the SNARE complex requires the ATPase N-ethylmaleimide-sensitive fusion protein (NSF). To determine where in the synaptic-vesicle cycle NSF functions, we have undertaken a genetic an...
متن کاملStructure of proteins involved in synaptic vesicle fusion in neurons.
The fusion of vesicles with target membranes is controlled by a complex network of protein-protein and protein-lipid interactions. Structures of the SNARE complex, synaptotagmin III, nSec1, domains of the NSF chaperone and its adaptor SNAP, and Rab3 and some of its effectors provide the framework for developing molecular models of vesicle fusion and for designing experiments to test these models.
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2008
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb.1450